Tag: in mice

CRISPR doubles lifespan of mice with rapid ageing disease progeria

CRISPR gene editing in mice has been used to correct a mutation that can cause rapid ageing, dramatically improving the animals’ health and lifespan Source: https://www.newscientist.com/article/2264168-crispr-doubles-lifespan-of-mice-with-rapid-ageing-disease-progeria/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=home…

Biomarker of Alzheimer’s Found To Be Regulated By Sleep Cycles

Following a 2018 study demonstrating how disrupted sleep can accelerate the buildup of toxic plaques associated with the disease, scientists from Washington University School of Medicine (WUSM) in St. Louis have now identified a protein implicated in the progression of the disease that appears highly regulated by the circadian rhythm, helping them join the dots and providing a potential new therapeutic…

Drug Reverses Age-Related Mental Decline Within Days

The University of California San Francisco issued this glowing announcement of some new research: Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic…

Reversal of Biological Clock Restores Vision In Old Mice

John Trumpian shares a report from SciTechDaily: Harvard Medical School scientists have successfully restored vision in mice by turning back the clock on aged eye cells in the retina to recapture youthful gene function. The team’s work, described today in Nature, represents the first demonstration that it may be possible to safely reprogram complex tissues, such as the nerve cells of…

No Implants Needed For Precise Control Deep Into the Brain

An anonymous reader quotes a report from IEEE Spectrum: In April, Guoping Feng and colleagues at MIT, along with [Karl Deisseroth, a neuroscientist and bioengineer at Stanford University] demonstrated a minimally invasive optogenetic system that required drilling a small hole in the skull, then being able to control opsin-expressing neurons six millimeters deep into the brain using blue light. This approach…

Scientists Say a Mind-Bending Rhythm In the Brain Can Act Like Ketamine

In mice and one person, scientists were able to reproduce out-of-body experiences often associated with ketamine by inducing certain brain cells to fire together in a slow-rhythmic fashion. The findings have been published in the journal Nature. NPR reports: “There was a rhythm that appeared and it was an oscillation that appeared only when the patient was dissociating,” says Dr. Karl…

Body fat transformed by CRISPR gene editing helps mice keep weight off

CRISPR gene editing can turn white fat cells into brown fat that burns energy, a technique that limited weight gain in mice and could potentially be used to treat obesity-related disorders Source: https://www.newscientist.com/article/2252925-body-fat-transformed-by-crispr-gene-editing-helps-mice-keep-weight-off/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=home…

Boosting gut microbes helps protect mice against Alzheimer’s disease

A prebiotic supplement that promotes good gut bacteria seems to protect against an Alzheimer’s-like disease in mice and will soon be tested in a clinical trial Source: https://www.newscientist.com/article/2250188-boosting-gut-microbes-helps-protect-mice-against-alzheimers-disease/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=home…

UC Berkeley Study Finds Diluting Blood Plasma Reverses Aging In Mice

schwit1 shares a report from Berkeley News: In 2005, University of California, Berkeley, researchers made the surprising discovery that making conjoined twins out of young and old mice — such that they share blood and organs — can rejuvenate tissues and reverse the signs of aging in the old mice. The finding sparked a flurry of research into whether a youngster’s…