Willem Dafoe and Robert Pattinson play two characters who experience extreme isolation in the film The Lighthouse, which has a drastic effect on their minds
Source:
https://www.newscientist.com/article/2231732-the-lighthouse-how-extreme-isolation-transforms-the-body-and-mind/?utm_campaign=RSS%7CNSNS&utm_source=NSNS&utm_medium=RSS&utm_content=home